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“(4) prescribe requirements respecting reports to 
be made by persons engaged in recombinant DNA proj T 
ects ; and 
“ (5) include such other provisions as the Secretary 
determines to be necessary for the effective administra- 
tion of the requirements of this part. 
“(b) The Secretary shall periodically review regula- 
tions promulgated under subsection (a) and promulgate such 
amendments to such regulations as the Secretary determines 
to be necessary. 
“(c) For purposes of this part, the term ‘recombinant 
DNA’ means molecules that consist of different segments 
of deoxyribonucleic acid which have been joined together 
in cell-free systems to infect and replicate in some host cell, 
either autonomously or on an integrated part of the host’s 
genome. 
“licenses 
“Sec. 472. (a) Effective one hundred and eighty days 
after the date of the enactment of this part, no person may 
engage in a recombinant DNA research project unless such 
person holds a license issued under this part authorizing such 
person to engage in such research project or is under the 
direct supervision of a person holding such a license. 
“(b) (1) A license to authorize a person to engage in 
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