6 
1 the advisory committee established under section 479 with a 
2 reasonable opportunity to provide him its recommendations 
3 on the issuance or renewal of such license. 
4 “ (3) In the case of a research project involving recom- 
5 binant DNA which under the guidelines referred to in section 
6 471 (a) (1) requires physical containment at the P-4 level 
7 prescribed by such guidelines, a license may not be issued 
8 under this section, during the six-month period beginning 
9 on the date of the promulgation of initial regulations under 
10 section 471, for the conduct of such project unless it is to be 
11 conducted at a center designated under section 473. After 
12 the expiration of such six-month period no license may be 
13 issued under this section for the conduct of a research project 
24 involving recombinant DNA which under the regulations 
25 promulgated under section 471(a) requires physical con- 
tainment equivalent to such P-4 level unless the project is to 
27 be conducted in such a center. The Secretary may require as 
28 a condition to the approval of a license for a project involv- 
-jy ing recombinant DA A which under such regulations requires 
20 physical containment at a level equivalent to the P-3 level 
22 prescribed by such guidelines that the project be conducted 
22 in such a center. 
23 “(c)( 1) Upon the issuance or renewal of a license under 
24 this section, the Secretary shall, except as provided in para- 
25 graph (2), publish in the Federal Eegister a detailed de- 
[ 548 ] 
