8 
1 “control of non-facility recombinant dna 
2 ACTIVITIES 
3 “Sec. 474. (a) The Secretary shall promulgate r^gula- 
4 dons to control the conduct of recombinant DNA activities 
5 described in section 473(a) (2). Such regulations shall — 
6 “ (1) prescribe physical and biological containment 
7 requirements for the conduct of such activities; 
8 “(2) apply as appropriate, to the conduct of such 
9 activities, the personnel safety requirements prescribed 
10 under section 475; 
11 “(3) include such special requirements as the 
12 Secretary determines necessary for the conduct of recom- 
13 binant DNA activities involving more than ten liters 
14 of recombinant DNA and for the conduct of any com- 
15 mercial recombinant DNA activity which the Secretary 
16 determines may present a significant risk to the public 
17 health and safety or the environment; and 
18 “(*) include such other provisions as the Score- 
19 tary determines to be necessary for the protection of the 
20 public health and safety and the environment. 
21 “(b) The regulations required by subsection (a) may 
22 not be initially promulgated unless the Secretary has pro- 
23 vided the advisory committee established under section 481 
24 with a reasonable opportunity to provide him its recom- 
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