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within one hundred and twenty days after the datp the peti- 
tion is received by the Secretary. If the Secretary approves 
such a petition, the Secretary shall, as soon as practicable 
after the date the petition is approved, commence a proceed- 
ing as requested by the petition. If the Secretary denies such 
a petition, he shall notify the petitioner of the denial and the 
reasons therefor and shall publish such reasons in tire Fed- 
eral Register. 
“ (4) (A) A license to authorize the conduct in a facility 
of any recombinant DXA activity which under the applicable 
physical containment requirements promulgated under para- 
graph (3) (A) (i) requires physical containment at the 
equivalent of the P-4 level prescribed by the guidelines 
referred to in section 472(a) (2), may only be issued, 
amended, or renewed by the Secretary, and the Secretary 
may issue, amend, or renew such a license only upon the 
recommendarion of the local biohazards committee with 
jurisdiction over such facility. 
“(B) a license to authorize the conduct in a facility 
of any recombinant DXA activity which under the applicable 
physical containment requirements promulgated under para- 
graph (3) (A) (i) requires physical containment at the 
equivalent of the P-3 level prescribed by the guidelines 
referred to in section 472 (a) , may be issued, amended, and 
renewed by a local biohazards committee if, within the thirty- 
1590] 
