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“(E) The issuance, amendment, and renewal of a single 
license to authorize the conduct of any combination of re- 
combinant DN A activities described in subparagraphs (A) , 
(B) , and (0) shall be carried out jointly 7 " by the Secretary 
and the local biohazards committee involved in accordance 
with guidelines prescribed by the Secretary. 
“(b) Any individual or public or private entity may 
apply for the issuance of a license under this section. An 
application for the issuance of a license shall be made in such 
form and manner as the Secretary shall prescribe and shall 
contain — 
“(i) a detailed description of each recombinant 
DNA activity to be conducted under the license applied 
for (including applicable research protocols, designs, and 
hypotheses) , identification of the professional personnel 
to be engaged in each such activity and their qualifica- 
tions, and a description of the facilities and materials to 
be used in each such activity; 
“(2) assurances satisfactory to the issuer of the 
license applied for that each recombinant DNA activity 
to be conducted under the authority of the license will 
be conducted in accordance with applicable physical and 
biological containment requirements prescribed under 
subsection (a) (3) (A) (i) ; 
“(3) assurances satisfactory to the issuer of the 
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