9 
1 “(2) apply as appropriate, to the conduct of such 
2 activities, the personnel safety requirements prescribed 
3 under section 475 ; 
4 “ (3) include such special requirements as the 
'5 Secretary determines necessary for the conduct of recom- 
6 binant I>NA activities involving more than ten liters 
7 of cell cultures containing recombinant DNA and for the 
8 conduct' of any commercial recombinant DNA activity 
9 which the Secretary determines may present a sig- 
10 nificant risk to health or the environment; and 
11 “(4) include such other provisions as the Secre- 
12 tary determines to be necessary for the protection of 
13 health or the environment. 
14 “(b) The Secretary shall consult with the Advisory 
15 Committee respecting the promulgation of the regulations 
16 required by subsection (a) (including the promulgation of 
17 amendments to such regulations other than amendments to 
18 make clerical or technical changes ) , and any notice of pro- 
19 posed rulemaking issued by the Secretary respecting such 
20 regulations shall contain any comments submitted to the 
21 Secretary by the Advisory Committee respecting such 
22 regulations. 
23 “(c) The regulations required by subsection (a) shall 
24 be initially promulgated within one year of the date of the 
11.11. 7897 2 
[ 626 ] 
