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enactment of this part and shall take eJTect upon the expira- 
tion of one hundred and eighty days from the date of their 
promulgation. 
“(d) The Secretary shall provide for an annual review 
of the regulations required by subsection (a) to determine, if 
their requirements continue to protect health and the 
environment. 
“(e) If the Secretary receives a petition for the pro- 
mulgation of a regulation to prescribe an additional require- 
ment under subsection (a) or to revise or repeal a require- 
ment contained in a regulation promulgated under that 
subsection, the Secretary shall, after consultation with the 
Advisory Committee, either approve or deny the petition 
within one hundred and twenty days after the date the 
petition is received by the Secretary. If the Secretary 
approves such a petition, the Secretary shall, as soon as prac- 
ticable after the date the petition is approved, commence a 
proceeding as requested by the petition. If the Secretary 
denies such a petition, he shall notify the petitioner of the 
denial and the reasons therefor and shall publish such reasons 
in the Federal Register. 
“licenses 
“Sec. 475. (a) (1) Licenses for facilities in which re- 
combinant LUST A activities are to be conducted shall be issued, 
amended, and renewed in accordance with this section. 
[ 627 ] 
