14 
1 “ (4) (A) A license to authorize the conduct in a facility 
2 of any recombinant DXA activity which under the applicable 
3 physical containment requirements promulgated under para- 
4 graph (3) (A) (i) requires physical containment at the 
5 equivalent of the P-4 level prescribed by the guidelines 
6 referred to in section 472(a) (2), may only he issued, 
7 amended, or renewed by the Secretary, and the Secretary 
8 may issue, amend, or renew such a license only if the Advi- 
9 sory Committee and the local biohazards committee with 
10 jurisdiction over such facility recommend that such license be 
11 issued, amended, or renewed. 
12 “(B) A license to authorize the conduct in a facility of 
13 any recombinant DXA activity which under the applicable 
14 physical containment requirements promulgated under para- 
15 graph (3) (A) (i) requires physical containment at the 
16 equivalent of the P-3 level prescribed by the guidelines 
17 referred to in section 472 (a) (2), may be issued, amended, 
IS and renewed by a local biohazards committee in accordance 
19 with this subparagraph. If the committee proposes to approve 
20 cm application for the issuance, amendment, or renewal of 
21 such a license, such committee shall submit to the Secretary — 
22 “ ( 1 ) the application for such action together with 
23 any materials submitted to the committee respecting the 
24 application, and 
25 “ (2) a statement of any conditions proposed to be 
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