15 
1 imposed by the committee on the approval of the 
2 application to assure that requirements under this part 
3 applicable to recombinant DNA activities which would 
4 be conducted under the license are complied with, 
5 and, within thirty days of the submittal of such application 
g and statement, the Secretary shall, in consultation with the 
7 Advisory Committee, review the application to determine if 
8 its approval would be in accordance with the requirements of 
9 this part. The Secretary, upon request of the Advisory Com- 
10 mittee, shall extend such thirty-day review period for an ad- 
11 ditional period of not to exceed sixty da}^s. The local bio- 
12 hazards committee may approve the application unless within 
13 the applicable review period the Secretary determines that 
14 it may not be approved. The Secretary shall, subject to sec- 
15 tion 480 , publish in the Federal Register the results of any 
lg application review conducted under this subparagraph, the 
17 comments of the Advisory Committee on such application, 
18 and if the Secretary did not disapprove an application which 
19 the Advisory Committee recommended be disapproved, the 
2Q reasons for not disapproving the application. 
21 “(C) A license to authorize the conduct in a facility 
22 of any recombinant DNA activity not described in sub- 
23 paragraph (A) or (B) may be issued, amended, and re- 
24 newed by a local biohazards committee. Upon the issuance, 
25 amendment, or renewal of a license by a local biohazards 
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