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tary may take such action with respect to the license as he 
determines is necessary, including revoking, suspending, or 
limiting the license. 
“(F) The issuance, amendment, and renewal of a single 
license to authorize the conduct of any combination of re- 
combinant BN A activities described in subparagraphs (A) , 
(B) , and (C) shall be carried out jointly by the Secretary 
and the local biohazards committee involved in accordance 
with guidelines prescribed by the Secretary. 
“ (b) Any individual or public or private entity may 
apply for the issuance of a license under this section, and the 
holder of a license may apply for its amendment or renewal. 
An application for the issuance or renewal or a license shall 
be made in such form and manner as the Secretary shall pre- 
scribe and shall contain — 
“ ( i ) a thorough description of each recombinant 
DNA activity to be conducted under the license (includ- 
ing applicable research hypotheses designs, and proto- 
cols) , identification of the professional personnel to be 
engaged in each such activity and their qualifications, 
and a description of the facilities and materials to be used 
in each such activity ; 
“(2) assurances satisfactory to the issuer of the 
license that each recombinant PiNA activity to be con- 
H.E.7897 3 
[ 635 ] 
