Recombinant DNA Advisory Committee - 7/31/90 
I. CALL TO ORDER AND OPENING REMARKS! 
Dr. Gerard G. McGarrity (Chair) called the meeting of the 
Recombinant DNA Advisory Committee (RAC) to order at 9:00 a.m., 
on July 31, 1990. He said a notice of the meeting had been 
published in the Federal Register on June 27, 1990, and that a 
quorum was present. He noted that the RAC is advisory to the 
Director of the National Institutes of Health and that times as 
published on the agenda were tentative. He called attention to 
the fact that Dr. Charles Epstein was attending his last meeting 
as a member of the RAC and thanked him for his contributions over 
the past 4 years. 
Dr. McGarrity then welcomed the following new members to the RAC: 
Dr. Ira Carmen from the Department of Political Science, 
University of Illinois; Dr. Anna Epps, Associate Dean for Student 
Services at Tulane University School of Medicine; Dr. Donald 
Krogstad, Departments of Medicine and Pathology, Washington 
University School of Medicine, St. Louis; and Dr. Leonard Post, 
Director of Molecular Biology Research at the Upjohn Company, 
Kalamazoo, Michigan. He noted that Dr. Susan Hirano of the 
Department of Plant Pathology at the University of Wisconsin had 
also been selected as a new member, but due to a scheduling 
conflict, was unable to attend the meeting. 
Dr. McGarrity welcomed Dr. LeRoy Walters, Chair of the Human Gene 
Therapy Subcommittee (HGTS) , and Dr. Robertson Parkman, a member 
of the Human Gene Therapy Subcommittee, as ad hoc consultants for 
this meeting of the RAC. 
Dr. McGarrity noted the following changes to the agenda. Item 
VII would not be considered because local review was incomplete. 
Item VIII was not submitted in time for inclusion in the Federal 
Register notice; therefore, no official vote could be taken on 
this matter although discussion could occur. Further, the 
protocol listed as Item VI was deferred by the HGTS and a summary 
of their actions would be presented. 
Dr. McGarrity noted that the monograph Gene Therapy for Human 
Patients has now been published and is available to the general 
public. It is a useful guide to explaining human gene therapy to 
a lay audience. He noted that there are additional copies of 
this monograph available for anyone who wishes to have them. 
Dr. McGarrity noted that the HGTS had met on July 30, 1990, and 
he thanked Dr. Walters and the members for doing a truly 
outstanding job. He said he had been involved in the formulation 
of review for human gene therapy for the last 5-6 years and that 
during this time the "Points to Consider for Protocols for the 
Transfer of Recombinant DNA into the Genome of Human Subjects" 
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Recombinant DNA Research, Volume 14 
