Part 2.B. >l 
Repeat above procedure for the growth and characterization of transduced/selected 
>l lymphocytes. 
Infuse 10® transduced and selected cells/kg. 
i approx. 4 weeks 
Infuse 3x10®/kg. 
i approx. 4 weeks 
Infuse 1x10®/kg. 
i approx. 4 weeks 
Infuse 2-3x1 0®/kg. 
Repeat infusions at this level for up to 6 treatments at monthly intervals. 
>1 
Comprehensive immune evaluation, 
i 
Continue periodic infusions if patient response is positive or begin course of 6 
approximately monthly ip infusions of 2-5x10® transduced/selected cells/kg. 
Repeat comprehensive immune evaluation 
12.0 References 
(1) Hirschhorn, R. 1983. Genetic deficiencies of adenosine deaminase and purine nucleoside 
phosphorylase: overview, genetic heterogeneity and therapy. Birth Defects. 19:73-81. 
(2) Giblett, E.R., J.E. Anderson, F. Cohen, B. Pollara, and H.J. Meuwissen. 1972. Adenosine 
Deaminase deficiency in two patients with severely impaired cellular immunodeficiency 
Lancet. 11:1067-1069. 
(3) Coleman, M.S., J. Donofrio, J.J. Hutton, L.Hahn, A. Daoud, B. Lampkin, and J. Dyminski. 
1978. Identification and quantification of adenosine deoxynucleotides in erythrocytes of 
a patient with adenosine deaminase deficiency and severe combined immunodeficiency. 
Biol. Chem. 253:1619-1626. 
(4) Cohen, A. R. Hirschhorn, S.D. Horowitz, A. Rubinstein, S.H. Polmar, R. Hong, and D.W. 
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