SCID-ADA deficient child receiving polyethylene-glycoi-ADA (PEG-ADA). Pediatric 
Research. 27:1 58A. 
(71 ) Sorenson, R.U., M. Berger and M.S. Hershfield. 1990. Self limited thrombocytopenia in 
a patient treated with polyethylene glycol (PEG) modified adenosine deaminase (ADA). . ' 
Pediatric Research 27:1 62A. 
(72) Terhune, P.E. Abdominal paracentesis. In: Oski, F.A, C.D. DeAngelis, R.D. Feigin, and J.B. 
Warshaw, eds. Principles and practice of pediatrics, ed 1. Philadelphia: J.B. Lippincott, 
1990:993. 
13.0 Appendix 
Appendix 13.1 
Figure 1 . Purine catabolic pathway demonstrating site of action of ADA. 
Figure 2. The effect of ADA gene insertion on the inhibitory effect of 2’deoxyadenosine on 
the proliferation of normal and ADA(-)SC1D T cells [TJF-2 cells] in vitro. 
Figure 3. ADA concentration in TJF-2 clones prepared immediately after transduction with 
the SAX vector. 
Appendix LASN. 
Specific data regarding characterization of the LASN retroviral vector. 
Appendix 13.2 
Figures 1-6. Characteristics of ADA(-) T cells transduced with the LASN vector. 
Appendix 13.3 
Figure 1 . Sperm whale myoglobin specific antibody responses of nude mice treated 
with human ADA gene-transduced murine T cells which had been maintained in 
culture for several months. 
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