Table 8 
Toxicicv of Treatmenc with Interleukln-2 
Total 
Number of patients _-652 
Number of courses _ 1039 
Chills 399 
Pruritus 180 
Necrosis 5 
Anaphylaxis ^ 1 
Mucositis (requiring liquid diet) 30 
Alimentation not possible 4 
Nausea and vomiting 666 
Diarrhea 596 
Hyperbilirubinemia (maximum/mg Z) 
' 2,1 - 6.0 547 
6.1 - 10.0 179 
10.1+ 83 
Oliguria 
<80 ml/8 hours 347 
<240 ml/24 hours 42 
Weight gain (7, body weight) 
0.0 - 5.0 377 
5.1 - 10.0 436 
10.1 - 15.0 175 
15.1 - 20.0 38 
20.1+ 13 
Elevated creatinine (maximum/mg %) 
2.1 - 6.0 637 
6.1 - 10.0 85 
10.1+ 10 
Hematuria (gross) 2 
Edema (symptomatic nerve or vessel compression) 17 
Tissue ischemia 2 
Resp. distress; 
not intubated 67 
intubated 41 
Bronchospasm 9 
Pleural effusion (requiring thoracentesis) 17 
Somnolence 114 
Coma 33 
Disorientation 215 
Hypotension (requiring pressors) 508 
Angina 22 
Myocardial infarction 6 
Arrhythmias 78 
Anemia requiring transfusion (number units transfused) 
1-15 377 
6-10 95 
11-15 24 
16+ 14 
Thrombocytopenia (minimum/mm^) 
<20,000 131 
20.001 - 60,000 361 
60.001 -100,000 285 
Central line sepsis 63 
Death 10 
Recombinant DNA Research, Volume 14 
