TABLE OF CONTENTS 
I. Call to Order 
Dr. Walters 4 
II. Interim Reports on the Human Gene Therapy Protocols 
Entitled Treatment of Severe Combined Immunodeficiency 
Syndrome (SCID) Due to Adenosine Deaminase (ADA) Deficiency 
with Autologous Lymphocytes Transduced with a Human ADA 
Gene and Gene Therapy of Patients with Advanced Cancer 
using Tumor Infiltrating Lymphocytes Transduced with the 
Gene Coding for Tumor Necrosis Factor 
Drs. Anderson and Wivel 4 
III. Addition to the Points to Consider Document to Expedite 
Minor ModiHcations on Approved Protocols 
Dr. Walters 5 
rv. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding a Human Gene Transfer Protocol Entitled BMT 9094 - 
Retroviral-Mediated Transfer of Bone Marrow Cells During 
Autologous Bone Marrow Transplantation for Acute Leukemia: 
Understanding Disease Recurrence IDv. Cornetta 
Dr. Gellert 5 
V. Registry of Patients Undergoing Human Gene Therapy Protocols 
Dr. Anderson 22 
VI. Future Role of the Human Gene Therapy Subcommittee 
Dr. Walters and Mr. Capron 22 
VII. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding a Human Gene Therapy Protocol Entitled The 
Administration of Interleukin-2, Interleukin-4, and Tumor 
Infiltrating Lymphocytes to Patients with Melanoma /D t. Lotze 
Dr. Parkman 23 
VIII. Proposed Addition to Appendix D of the NIH Guidelines 
Regarding Human Gene Transfer Protocol Entitled Autologous 
Bone Marrow Transplant for Children with Acute Myelogenous 
Leukemia (AML) in First Complete Remission: Use of Marker Genes 
to Investigate the Biology of Bone Marrow Reconstitution and the 
Mechanism of Relapse /D t. Brenner 
Dr. Mclvor 28 
Recombinant DNA Research, Volume 14 
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