Planning Subcommittee - 12/06/90 
Amend Section I-C-2 and Delete Section III-A-2 of the "NIH Guidelines” regarding 
Deliberate Release. 
On December 6, 1990, the Planning Subcommittee met and made a series of 
recommendations for the Recombinant DNA Advisory Committee. Among these 
recommendations was the proposal to modify the NIH Guidelines to eliminate the 
Recombinant DNA Advisory Committee review of experiments involving deliberate 
environmental release of any organism containing recombinant DNA except certain 
plants as described in Appendix L. 
Section I-C-2 currently reads: 
"I-C-2. If they involve deliberate release into the environment or testing in humans of 
materials containing recombinant DNA developed with NIH funds, and if the institution 
that developed those materials sponsors or participates in those projects. Participation 
includes research collaboration or contractual agreements, but not mere provision of 
research materials." 
Proposed amendment of this section reads: 
"I-C-2. If they involve testing in humans of materials containing recombinant DNA 
developed with NIH funds, and if the institution that developed those materials sponsors 
or participates in those projects. Participation includes research collaboration or 
contractu^ agreements, but not mere provision of research materials." 
Section III-A-2 currently reads: 
"III-A-2. Deliberate release into the environment of any organism containing 
recombinant DNA except those listed below. The term deliberate release' is defined as 
a planned introduction of recombinant DNA-containing microorganisms, plants, or 
animals into the environment. 
"III-A-2-a. Introductions conducted under conditions considered to be accepted scientific 
practices in which there is adequate evidence of biological and/or physical control of the 
recombinant DNA-containing organisms. The nature of such evidence is described in 
Appendix L. 
"III-A-2-b. Deletion derivatives and single base changes not otherwise covered by the 
Guidelines. 
"III-A-2-C. For extrachromosomal elements and microorganisms (including viruses), 
rearrangements and amplifications within a single genome. Rearrangements involving 
Recombinant DNA Research, Volume 14 
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