ASSENT FORM 
Patient Age 7-18 Years for Bone Marrow Transplant 
ASSENT 
You are in remission from AML which means we cannot sec any leukemia cells in your bone 
marrow or spinal fluid. There is a good chance your leukemia will return if you do not have 
further treatment. We would like to stop your leukemia from coming back by performing* 
a bone marrow transplant using your own bone marrow. Before we do the bone marrow 
transplant we will examine you to be sure you can have the transplant. We will also test you 
for certain viruses including the virus for AIDS. 
First, we will take a small part of your bone marrow out while you are asleep in the 
operating room. Since you will be sleeping, you will not feel us take the marrow. V^en you 
wake up, you may have some pain but you will receive medicine to make this feel better. 
Your bone marrow will be frozen for later use. 
At a later time, you will come into the hospital and receive high-dose drugs that will stop 
your blood forming cells from growing. We hope these drugs will also get rid of your 
leukemia and stop it from coming back. We will then thaw your marrow and give it to you 
so your blood forming cells will grow again. 
MARROW MARKING 
If you agree we will take a part (one-third) af the bone marrow that we remove from you 
and mix it with a special virus to mark the cells. If there were leukemic cells in your bone 
marrow when we stored it, we may be able to mark the cells and tell if your leukemia 
coming back from the bone marrow we gave you. This virus may mark 1 in 20 of your 
normal cells so we can watch them grow back after your bone marrow transplant. We hope 
that we will learn more about your leukemia in this way and one day be better able to help 
you or others. 
HIGH-DOSE CHEMOTHERAPY 
You will receive a drug called busulfan by mouth 4 times each day for four days (total 16 
times). You will then receive a second drug called cytoxan given by vein daily for four days. 
If leukemic cells are found in your spinal fluid, you will also receive spinal taps with 
medicine. 
BONE MARROW TRANSPLANT 
After the high-dose drug therapy you will have a day of rest and then your frozen bone 
marrow will be thawed and given back to you by your central catheter. An extra amount of 
blood will be taken once or twice a week for six weeks, and then monthly for six months, and 
then every six months for two years, and finally once a year for two years afterwards to test 
how the marrow cells are growing. You will also receive a total of eight bone marrow 
aspirates to judge how well your marrow is growing and whether the marked cells are 
present. If you had leukemic cells in your spinal fluid before transplant, you will receive an 
Recombinant DNA 
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