12.4.3 Radiographic Evaluation 
Routine chest x-ray (PA and lateral) 
CT scan, MRI or bone scan as clinically indicated for measurable 
disease. 
13.0 EVALUATION DURING STUDY 
13.1 Clinical 
Appropriate physical evaluation with chart documentation as suggested by the 
patients clinical course, but at least 3 times weekly. 
13.2 Laboratory Evaluation 
Daily CBC, differential and platelet counts until self-sustaining 
Reticulocyte count as indicated 
Daily electrolytes while on intravenous fluids and or hyperalimentation. As 
clinically indicated in other circumstances. 
Three x weekly SGOT/SGPT, Ca, Mg until discharge from inpatient unit, and 
as clinically indicated thereafter. 
Weekly for 6 weeks, monthly for 6 months and annually for 5 years analysis 
and separation by FACS of peripheral blood nucleated cells with sorting into 
granulocytes, monocytes, T cells and B cells and subsequent analysis for 
marker gene insertion (see protocol). Such studies should limit the amount 
of blood removed to 20-40 ml. 
Viral, bacterial, and fungal cultures as clinically indicated. 
Bone marrow aspirate as clinically indicated post ABMT for diagnosis and 
documentation of marrow recovery, and at day 30 and 60 for analysis of 
engraftment and the presence of the neogene. 
13.3 Radiographic evaluation 
Chest and other diagnostic radiographs as clinically indicated. 
Recombinant DNA Research, Volume 14 
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