I do give permission for gene marking 
I do not give permission for gene marking 
HIGH-DOSE CHEMOTHERPY 
Soon after bone marrow harvest, chemotherapy will start. A drug called carboplatin will be 
given by vein every other day over one hour for three doses. Then a drug VP- 16 is given by 
vein at the end of every other day over six hours for three days. 
BONE MARROW TRANSPLANT 
You (your child) will rest for two days after the chemotherapy. Then the bone marrow that 
was taken out before will be put back through an IV catheter. So that we can study the 
marked cells, we will take a little extra blood after the marrow is put back. The extra blood 
taken will be about 20 mL (1 tablespoon) once or twice a week for 6 weeks. We will also 
take extra blood monthly for 6 months, every six months for 2 years, and then once a year 
for 2 years. Bone marrow aspirates and biopsies will be done on days 21 and 32 after the 
transplant. Bone marrow aspirates will also be done after you are (your child is) well to see 
how the graft is working. We will take these samples every 6 months for 2 years and then 
once a year for 2 years. Any marrow that you do not need (your child does not need) may 
be used for research. 
LONG-TERM FOLLOW UP 
We will follow your (your child’s) progress over a long period. You (your child) will need 
to be examined yearly for 14 years after the transplant. After the first 4 years this can be 
done by you (your child’s) local doctor. A teaspoon of blood will be taken at each exam. 
CONFIDENTIALITY 
Your (your child’s) case will be treated in complete confidence, unless you specifically agree 
otherwise. However, approved people from Government agencies may review the charts. 
SIDE EFFECTS 
The drugs in this study will cause some bad side effects. Doctors will watch you (your child) 
carefully to prevent these effects or make them less severe. Bone marrow transfusion can 
also produce very serious side effects. The Carboplatin and VP-16 destroy normal bone 
marrow and can cause severe infections and bleeding. You will need antibiotics, blood 
transfusions and possibly a medicine called amphotericin B for fungal infections. Also, the 
transfused marrow does not "take" in some cases (1 in 20 cases at other centers). If this 
happens, a second marrow transfusion may be given. The table below lists the possible 
short-term and long-term side effects. 
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Recombinant DNA Research, Volume 14 
