HEPATOCELLULAR TRANSPLANTATION AND TARGETING GENETIC MARKERS TO HEPATIC CELLS 
1 
y 
2. Initial evaluation. The initial evaluation will be performed as described in the 
"Clinical Course and Management of Hepatic Transplantation". The following tests are 
included in the conventional evaluation for OLT at TCH: 
Table 1. Conventional clinical evaluation for OLT (see also Appendix E) 
- liver biopsy (if clinically indicated. Most patients have at least one biopsy 
prior to, or at the time of, the initial TCH evaluation.) 
- Hepatitis profile - HBSAG, anti-HBS, anti-HBC, anti-HAV 
- Tissue typing 
- Fungal battery 
- Chem 20 
- CBC 
- PT, PTT 
- prealbumin 
- CMV, HSV, Toxoplasma, Varicella, RPR, HIV culture/titers 
- prealbumin 
- CXR 
- EKG 
- 2-D echocardiography 
- Liver ultrasound 
- Doppler ultrasound of hepatic vasculature and inferior vena cava 
- MRI/CT scan 
- Pulmonary function tests 
The following tests will be performed as part of the research component of "Clinical 
Course and Management of Hepatic Transplantation" . ilj 
Table 2. Prior clinical research investigations to be performed in selecting study ] 
participants (see also Appendix E) I 
- Lidocaine loading (MEGX) for assessment of residual hepatic function (Oellerich . 
et al, 1987; 1989; 1990). 
- Metabolic tests to determine residual metabolic capacity of the diseased liver: 
baseline metabolic functions, phenylalanine loading tests for aromatic amino acid 
metabolism, allopurinol loading test for carbamyl phosphate synthase (urea cycle) 
metabolism (Hauser et al, 1990). 
- Electroencephalogram 
- Nutritional assessment, including basal metabolic rate and Total Body Electrical^ 
Conductance (Fiorotto et al, 1987; Presta et al, 1983). 
- Psychological assessment 
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Recombinant DNA Research, Volume 14 
