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PRINCIPAL INVESTIGATOR/PROGRAM DIRECTOR Mirh^pl T 
BIOGRAPHICAL SKETCH 
Give the following information for the key personnel and consultants listed on page 2. Begin with the Principal 
Investigator/Program Director. Photocopy this page for each person. 
NAME 
Michael T. Lotze, M.D. 
POSITION TITLE AsSOC . Dir. Pi t IfilRTHDATE CMo.. Day, Vr.; 
Cancer Institute; Professor 
of Surgery. Dir. Surg. Oncol. 
07-11-52 
EDUCATION (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.) 
INSTITUTION AND LOCATION 
DEGREE 
YEAR 
CONFERRED 
FIELD OF STUDY 
N.U. Honors Program In Medical Education, 
B. Med. Sc: 
.. 1973 
Premedical Studies 
Evanston, 111. 
Northwestern Medical School, Chicago, 111. 
MD 
1974 
Medicine 
RESEARCH AND PROFESSIONAL EXPERIENCE Concluding with present position, list, in chronological order, previous employment, expenence 
and honors. Include present memoership on any Federal Government public advisory committee. List, in chronological order, the titles and corr 
plete references to all publications during the past three years and to representative earlier publications pertinent to this application. DO NO 
EXCEED TWO PAGES. 
1975 
1975-1977, 1980-1982 
1977- 1978 
1978- 1980 
1982-1990 
1990-Present 
Jr. Medical Fellow in Surgery. M.D. Anderson Tumor Institute, Houston, Texas 
Intem/Resident in Surgery Strong Memorial Hospital, Rochester, New York 
Medical Officer, National Health Service Corps, Onamla, Minnesota 
Staff Fellow, Surgery Branch, National Cancer Institute, Bethesda, Maryland 
Senior Investigator, Surgery Branch, National Cancer Institute, Bethesda, Maryland 
Director, Division of Surgical Oncology, Dept of Surgery and Associate Director, 
Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 
Awards and Honors : 
1971-1974 Honors Program in Medical Education, Northwestern University 
1982 Robert H. White Award for Excellence in Teaching, University of Rochester 
1 986 4th Annual Edith Hamilton Cancer Lecturer, Rochester, New York 
1987 Special Achievement Award; DHHS, NIH. 
1988 4th Vender Lecturer, Northwestern University, Evanston, Illinois 
SELECTED PUBUCATIONS (out of 135) 
Lotze, M.T., Strausser. J.L, Rosenberg, S.A: In vitro growth of cytotoxic human lymphocytes. II. Use of 
T cell growth factor (TCGF) to done hunr^n T cells. J. Immunol. 124:2972-2978. 1980. 
Lotze, M.T., Lines, B.T., Mathisen, D.J., Rosenberg. S.A: The in vitro distribution of cultured autologous 
human arxl murine lymphoid cells grown in T cell growth factor (TCGF): Implications for the adoptive immuno- 
therapy of tumors. J. Immunol. 125:2972-2978. 1980. 
Lotze, M.T., Grimm, E.A, Mazumder, A, Strausser, J.L, Rosenberg. S.A: Lysis of fresh and cultured autologous 
tumor by lymphocytes cultured in T cell growth factor (TCGF). Cancer Res. 41:4420-4425, 1981. 
Donohue, J.H., Lotze, M.T., Robb, R.J., Rosenstein, M., Brazlel, R.M., Jaffe, E.S., Rosenberg, S.A: In vitro 
administration of purified Jurkat derived lnter1eukin-2 in mice. Cancer Research. 44:1380-1386. 1984. 
Lotze, M.T., Frana, LW., Sharrow, S.O., Robb, R.J., Rosenberg, S.A: In vivo administration of purified human 
lnter1eukin-2 I. Half life and immunologic effects of the Jurkat cell line derived IL-2. J. Immunol. 124:157-166, 198£ 
Lotze, M.T., Matory, Y.L, Ettinghausen, S.E., Rayner, AA, Sharrow, S.O.. Seipp, C.AY., Custer, M.C., 
Rosenberg. S.A: In vivo administration of purified human inter1eukin-2. II. H^ life, immunologic effects 
and expansion of peripheral lymphoid cells in vivo with recombinant IL-2. J. Immunol. 135 2865-2875, 1985. 
Lotze, M.T., Custer, M.C., Sharrow, S.O., Rubin, LA. Nelson, D.L, Rosenberg, S.A: In vivo administration of 
purified human lnter1eukin-2. III. Development of Tac positive cells and circulating soluble IL-2 receptors following 
IL-2 administration to humans. Cancer Res. 47:2188-2195. 1987. 
Recombinant DNA Research, Volume 14 
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