THE JOHNS HOPKINS UNIVERSITY 
SCHOOL OF HYGIENE AND PUBLIC HEALTH 
615 North Wolfe Street 
Baltimore. Maryland 21205. U.S.A. 
DEPARTMENT OF BIOCHEMISTR Y 
ISO 1 1 933-3671 
November 10, 1977 
Dr. Donald S. Fredrickson 
Director, National Institute of Health 
Bethesda, Maryland 20014 
Re: Revised Recombinant DNA Guidelines 
Dear Dr. Fredrickson: 
Those of us on the Institutional Biohazards Committee have found it 
difficult to identify all the changes proposed in the 'Guidelines issued 
September 27, 1977. It would be helpful if in the final form the changes 
were boldly identified. If not that, a list of the changes accompany 
each copy. 
I apologize for the tardiness of this comment. 
Sincayely yours, 
Roger M. Herriott 
Chairman, J.f+.U. 
Biohazards Committee 
[Appendix A — 54] 
