- 2 - 
6. p. 49603, Col. 1, line 69. Insert after "above)": 
" , except that it is not required that the virus be unable to 
replicate in mouse cells". 
- This removes an unnecessary restriction which is valid 
for polyoma virus but not for viruses that will not be studied in 
mouse cells and which will be worked with in P 4. 
7. p. 49603, Col. 2. After line 27 insert: 
"(3) Mouse adenovirus as a_ candidate vec tor . This virus may 
qualify in the near future as a cloning vector, and would offer distinct 
safety features. In particular, the fact that insofar as is known, it 
replicates only in mouse cells makes it a desirable vector. If additional 
data are obtained which in the judgment of this Committee show that mouse 
adenovirus meets the general requirements above, it can be used as a 
cloning vector under the conditions specified for polyoma virus in 
section III. B. 3.(1) above." 
- This is a possibly important new development and should not 
be excluded from the guidelines. 
8. p. 496Q3, Col. 2, line 57. After the word "if" insert: "in 
the judgment of this Committee" 
- This clarifies the mechanism for making the decision as 
to whether the data are adequate. 
A copy of the Register with the locations marked is attached. 
I am sending a copy of this to the Committee members for their possible 
comments. 
Wallace P. Rowe, M.D. 
I Enel 
as 
*9 
[Appendix A — 56] 
