B. Specific Comments. 
The paragraph notations in the following part of these comments 
correspond to that appearing in the "Recombinant DNA Research Pro- 
posed Revised Guidelines", Federal Register, September ST, 1977, 
part III. 
I. Introduction. 
We are in agreement with the exclusion of recombinant DNA 
molecules formed from any combination where the components are 
derived from genomes known to replicate within the organism used 
to propagate the recombinant molecules; however, we would suggest 
adding to the non-exclu&ed exceptions described in footnote 1. those 
DNA 1 s derived from recombination experiments involving bacterial 
pathogens. 
»*■*■**** 
The question of protection of confidential information as it 
affects commercial, competitive enterprise arises throughout the 
guidelines and the proposed revision. We recommend that an 
acknowledgment of the need for such protection be recognized and 
that suitable statements be included in the introduction to ensure 
confidentiality when necessary. Under the Freedom of Information 
Act, research protocols, designs, data, and other research results 
become publicly available within the context of the current and 
proposed guidelines. If the guidelines are extended to cover non- 
federally funded research, provision must be made to protect 
proprietary interests. 
[Appendix A — 40] 
