RCA DEC 09 0639* 
HbWNIH BHDA A 
4b 1 562 DKFZ D 
FS NR. 652 1 8. 12.77 
TO THE DIRECTOR DR. D. FREDRICKSON 
FROM EMBO STANDING ADVISORY COMMITTEE ON RECOMBINANT DNA RESEARCH 
DRAFT REPORT ON REVISED NIH GUIDELINES 
PROPOSED REVISIONS TO THE NIH GUIDELINES 
GENERAL COMMENTS 
IN JUNE 1976 THE -NIH OF THE USA ISSUED GUIDELINES FOR RESEARCH 
INVOLVING RECOMBINANT DNA MOLECULES* IT BEING UNDERSTOOD THAT 
PERIODIC REVISIONS WOULD BE MADE TO THE GUI DELINS IN THE LIGHT 
OF FURTHER KNOWLEDGE AND EXPERIENCE. DURING THE SUMMER OF 1977 
THE NIH ADVISORY COMMITTEE BEGAN THE PROCESS OF REVISING THE 
GUIDELINES AND PROPOSED REVISED GUIDELINES WERE PUBLISHED IN THE 
FIR^T ISSUE OF THE NIH’S RECOMBINANT DNA TECHNICAL BULLETIN. THE 
EMBO COMMITTEE HAS DISCUSSED IN SOME DETAIL THE REVISIONS THAT 
ARE PROPOSED AND HAS REACHED THE CONCLUSIONS REPORTED IN THE 
FOLLOWING PARAGRAPHS. THE EMBO COMMITTEE WILL CONVEY BY LETTER 
[Appendix A — 86] 
