PRINCIPLE THAT* FOR CERTAIN EXPERIMENTS* IF BIOLOGICAL CONTAIN- 
MENT IS INCREASED BY ONE STEP A REDUCTION OF ONE STEP IN SPECIAL 
CONTAINMENT EQUIPMENT CAN BE ALLOWED* AND CONVERSELY* THAT 
BIOLOGICAL CONTAINMENT CAN BE REDUCED BY ONE STEP WHEN THE PHYSICAL 
CONTAINMENT EQUIPMENT IS INCREASED BY ONE STEP. THESE CHANGES ARE 
ENVISAGED BY THE NIH COMMITTEE FOR P3 AND PA PHYSICAL CONTAINMENT 
AND FOR EK1 AND EK2 BIOLOGICAL CONTAINMENT. THE EMBO COMMITTEE 
PROPOSES THAT THEY BE EXTENDED TO P2 AND P3 PHYSICAL CONTAINMENT 
SUCH THAT A COMBINATION OF A LABORATORY DESIGNED TO P2 
SPECIFICATIONS WITH A CLASS 3 CABINET EXHAUSTING TO THE OUTSIDE 
AIR* BE CONSIDERED EQUIVALENT TO A LABORATORY DESIGNED AND 
EQUIPED TO P3 SPEC I FI CAT! ONS . 
CATEGORIZATION OF SAFETY MEASURES FOR PARTICULAR CLASSES OF 
EXPERIMENTS 
THE EMBO COMMITTEE TAKING INTO CONSIDERATION THE NEW DATA 
MENTIONED ABOVE IN PARAGRAPH 3.3* BELIEVES THAT FOR 'SHOTGUN* 
EXPERIMENTS INVOLVING TISSUE FROM HEALTHY ORGANISMS THE BASIC 
COMBINATIONS OF BIOLOGICAL AND PHYSICAL CONTAINMENT SHOULD BE 
THOSE i>HOWN IN COLUMN 1 OF TABLE 1 • FOR COMPARISON COLUMN 2 OF 
TABLE 1 SHOWS THE CONTAINMENT COMBINATIONS PROPOSED IN THE 
RfcVlaaD NIH GUIDELINES. THE EMBO COMMITEE'S RECOMMENDATIONS RELAX 
THE CONTAINMENT COMBINATIONS FURTHER THAN THE PROPOSALS OF THE NIH 
ADVISORY COMMITTEE. THE FORMER DOES NOT BELIEVE PRIMATE DNA TO BE MORE 
HAZARDOUS THAN THE DNA OF OTHER MAMMALS AND BIRDS, AND NONE OF THE EXISTING 
[Appendix A — 90] 
