DONOR DNA FROM AN EUKARYOTE NOT 
SUSCEPTIBLE TO THE VECTOR - MEDIUM LEVEL PHYSICAL CONTAINMENT 
DONOR DNA FROM A PROKARYOTE - HIGHER LEVEL PHYSICAL CONTAINMENT 
FOR EXAMPLE CLONING OF MOUSE DNA UsING POLYOMA VIRUi AS A VECTOR 
AND LOUSE Cc.LLs Hi huo'i iHOULD NOT REQUIRE PRECAUTIONS MORE STRINGENT 
THAN THOiE ROUTINELY USED FOR MANY YEARS IN LABORATORIES STUDYING 
POLYOMA VIRUS INFECTION OF MOUSE CELLS AND MICE® 
THE EMBO COMMITTEE FINDi THE PROPOSALS FOR THIS CLASS OF EXPERIMENTS 
IN THE REVISED NX H GUIDELINES NOT SUFFICIENTLY DISCRIMINATING 
BECAUSE THEY WOULD IMPOSE UNNECESSARILY HIGH LEVELS OF PHYSICAL 
CONTAINMENT FOR EXPERIMENTS WITH MANY EUKARYOTIC DNAS « 
INTERNATIONAL SHIPMENT AND EXCHANGE OF RECOMBINANT DNA SEQUENCES 
THE EMBO COMMITTEE BELIEVES THAT THE PACKAGING AND SHIPMENT OF 
SAMPLES OF ORGANISMS CONTAINING RECOMBINANT DNA MOLECULES SHOULD 
3E IN ACCORDANCE WITH ACCEPTED INTERNATIONAL PROCEDURES « IT ALSO 
BELIEVES THAT IN PRINCIPLE THERE SHOULD BE NO RESTRICTIONS ON THE 
EXCHANGE OF SAMPLES OF RECOMBINANT DNAS OR ORGAISMS HARBOURING 
THEM BETWEN SCIENTISTS WORKING IN COUNTRIES THAT HAVE ADOPTED 
APPROPRIATE GUIDELINES WHICH ENSURE EQUIVAVENT SAFEY PRECAUTIONS* 
BEFORE A SHIPMENT IS SENT* HOWEVER* THE DONOR SHOULD BE PROVIDED* 
[Appendix A — 95] 
