Dr. Donald S. Fredrickson 
2 
December 5, 1977 
pathogen, thus the pathogen has to be in close association with the host. Certain 
plant pathogenic species, of course, should be under stringent containment and 
restrictions for their containment have been already written into law; that is, 
organisms of serious agricultural threat are under existing quarantine laws and 
regulations. 
Attached to this letter is a classification based on above considerations in 
more detail for your consideration and for consideration by the Advisory 
Committee. The classification provides a realistic view of the status of 
plant pathogenic species by mainly weighing its economic importance, geographic 
isolation and cosmopolitan nature. It is difficult to perceive any potential 
agricultural hazard generated when plant pathogenic prokaryotic genes are clones 
into JE. coli K12, the habitat of which is clearly not on plants. 
Sincerely yours 
Clarence I. Kado, Professor 
Member of the Recombinant DNA Advisory Committee 
American Phytopathologies! Society 
Member of the Recombinant DNA Research 
Subcommittee, NSF/USDA 
Nick J. Panopoulos, Associate Professor 
Member of the Recombinant DNA Advisory Committee 
American Phytopathological Society 
Member of the Recombinant DNA Research 
r 
A Advisory Committee 
American Phytopathological Society 
George Jtsruening, Froressor 
Member of the Recombinant DNA Advisory Committee 
American Phytopathological Society 
Member of the Campus Subcommittee on Recombinant 
DNA 
CIK: rl 
Enel . 
cc: William J. Garland, Jr. 
John W. Littlefield 
Peter R. Day 
Mary E. Clutter 
John Fulkerson 
Charles Lewis 
Arthur Kelman 
[Appendix A — 99] 
