NATIONAL RESEARCH COUNCIL 
ASSEMBLY OF LIFE SCIENCES 
2101 Constitution Avenue Washington, D. C. 20418 
DIVISION OF MFDICAL SCIENCES 
December 13, 1977 
Dr. Donald S. Fredrickson 
Director 
National Institutes of Health 
Building 1, Room 124 
9000 Rockville Pike 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson: 
Dr. Philip Handler, President of the National Academy of 
Sciences, has requested that the attached statement of the 
Committee on Laboratory-Created Biohazards of the National 
Research Council be forwarded to you. The statement is in 
response to your request for comments on the "Revised Guide- 
lines for Recombinant DNA Research." 
The Committee is composed of Maclyn McCarty, Chairman, 
Paul Berg, Clifford Grobstein, Cyrus Leventhal , Charles Rammel- 
kamp, Arthur Kelman, Charlotte Friend, Herman Eisen, and Rollin 
Hotchkiss . 
I trust that the statement will be of use to you in your 
deliberations . 
Sincerely yours 
Daniel L. Weiss, M.D. 
Executive Secretary 
DLW : j dn 
Attachment 
cc: Dr. McCarty 
[Appendix A — 123] 
'lie National Research Council is the principal operating agency of the National Academy of Sciences and the National Academy if Engineering 
to serve government and other organizations 
