^ Max O. Schultze, Apt. 211 
2201 Ambassador Road N. E 
14 January 1978 | Albuquerque, N. M. 87112 
Dr. Donald Fredrickson, Director 
National Institutes of Health 
Bethesda, Maryland 20014 
Dear Dr. Fredrickson* 
Re* Recombinant DNA 
In the January 9 issue of Chemical & Engineering 
News I have seen a report by Jeffrey L. Fox on the Decem- 
ber 1977 raeetint on revision of the NIH guidelines 
on recombinant DNA. 
As a biochemist, now retired, I have followed 
the developments in this area with much interest and 
some concern. 
It is timely, no doubt, to revise some of the 
current guidelines. I imagine that heavy demands are 
being made to relax the current restraints, based on 
claims of current evedence, largely unpublished, that 
the potential dangers have been exaggerated, 
I believe that the restrictions now in force are 
generally sound and prudent and that they permit the 
accumulation of extensive and sound evidence which is 
so much needed before restraints are relaxed. 
I am writing to urge that a very conservative 
and cautious stance be adopted while the proposed amend- 
ments are being considered. I trsut that severe penal- 
ties will be invoked against institutions in which 
violations take place. 
Very truly yours, 
Max 0. Schultze 
[Appendix A — 217] 
