New Haven, Connecticut 06510 
SCHOOL OF MEDICINE 
333 Cedar Street 
Department of Human Genetics 
April 21, 1978 
To: 
From: 
Dr. Donald Frederickson 
Edward A. Adelbei 
The enclosed letter deals only with "self-cloning" experiments in 
E. coli , but several Biohazard Committee Chairmen have noted that the 
same appeal should be made on behalf of all self-cloning experiments, 
such as B. subtilis genes in 13. subtilis , etc. 
EAA:bgf 
Enclosure 
[Appendix A — 290 ] 
