A 4 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 
Dr. Joseph G. Perpich 
Associate Director for Program 
Planning and Evaluation 
Public Health Service 
National Institutes of Health 
Bethesda, HD 20014 
Dear Dr. Perpich: 
The attached comments on the proposed revision to the Recom- 
binant DNA Guidelines were prepared by Dr. Arthur Saz of my staff 
and are forwarded for your consideration. 
o 
X 
WASHINGTON. D.C. 20460 
MAY 4 1C‘3 
OFFICE OF 
RESEARCH AND DEVELOPMENT 
Sincerely yours, 
Delbert S. Barth, Ph.D. 
Deputy Assistant Administrator 
for Health and Ecological Effects 
Enclosure-1 
[Appendix A — 298] 
