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(2) The Secretary may, by regulation, amend in any 
manner any of the requirements in effect under paragraph 
(1) if he determines that the requirements in effect after 
such amendment will be sufficient for the protection of health 
and the environment. A regulation promulgated under this 
paragraph shall be promulgated in accordance with section 
553 of title 5, United States Code. 
(3) Before the expiration of the ten-day period begin- 
ning on the date of the enactment of this Act, the Secre- 
tary shall take such action as may be necessary to publicize 
and make available the requirements described in paragraph 
( 1 ) , including the publication of such requirements in the 
Federal Register. 
(b) The Secretary may, by order, exempt, under such 
terms and conditions as the Secretary shall include in the 
order, from the requirements of subsection (a) (1) any 
recombinant DNA activity which the Secretary finds does 
not present a significant risk to health or the environ- 
ment. Each such order shall be published in the Federal 
Register together with a statement of the basis for the 
order. 
(c) (1) Each individual or entity which, on the tenth 
day after the date of the enactment of this Act, is responsible 
for the conduct of any recombinant DNA activity shall, in 
accordance with regulations promulgated under subsection 
[Appendix B — 7] 
