2 
* * * the degree to which appropriate groups were involved 
in the evaluation of the recombinant DNA issue * * * 
* * * the impact on basic research scientists of the intense 
public scrutiny of recombinant DNA research * * * 
* * * efforts at international coordination as a result of the 
DNA recombinant molecule research debates * *' * 
* * * the NIH DNA recombinant molecule research guidelines 
as a means for regulating basic research in this area * * * 
* * * the probability that the NIH guidelines will be followed ; 
the procedures for insuring compliance * * * 
* * * the significance of the new concerns of local biohazards 
committees for basic research programs when Federal preemption 
appears to be warranted for the achievement of standard 
Regulations * * * 
^ * * * the significance of health and safety issues identified 
in recombinant DNA research issues with regard ttf other 
biomedical research subjects with some potential for hazard to 
the public health * * * 
* * * alleviation of concerns for the public health without 
stifling basic research incentives * * * 
* * * implications for trade secret protection, patent laws, 
and the protection of research grant proposals in the demand for 
increased public access to all phases of basic research planning 
* * * use of the patent process as a technique for regulating 
basic research * * * 
* * * methodologies for dealing with risk-benefit assessments 
when data are incomplete or inadequate * * * 
* * * the difficulty of the quantification of value judgments 
which are required for policy decisions * * * 
* * * need for new institutional arrangements to facilitate 
public debate on value laden Issues associated with basic research 
* #' * 
* * * increasing the effectiveness of representative government 
in dealing with public policy issues involving low probabilities of 
a very high consequence catastrophe * * * 
* * * factors involved in developing science poficies for short-, 
medium-, and long-range potential hazards * * * 
* * * problems with current risk-benefit assessments which 
preclude the use of traditional methods for evaluation of issues 
involving a high content of value and ethical decisions * * * 
* * * the appropriate role for the Congress in debates which 
involve ethics and values affecting the determination of research 
priorities * * * 
* * * maintaining the right to freedom of inquiry while 
providing for the right of the public to protect itself against 
potential hazards from basic research * * * 
* * * the constitutionality of the right to restrict research on 
the basis of conjectured hazards * * * 
* * * the basis of the concern of sonie scientists that proposed 
regulation of recombinant DNA research represents a threat to 
freedom of inquiry * * * 
[Appendix B — 53] 
