6 
the people living in Frederick County, Maryland, including 
plaintiff. 
14. The present state of the science is not sub- 
stantially progressed past that which existed at the time 
Dr. Robert Sinsheimer, Chairman of the Division of Biology, 
California Institute of Technology at Pasadena, California, 
wrote in "New Scientists", on October 16, 1975: 
"Briefly, it became apparent to the 
scientists involved at almost the last 
hour when all of the techniques were 
really at hand that they were about 
to create novel forms of self-propagating 
organisms, derivatives of strains known 
to be normal components of the human 
intestine flora with almost completely 
unknown potential for biological havoc. 
Could an Escherichia coli strain 
carrying all or part of an oncogenic 
/cancer causing/ virus become resident 
in the human intestine? Could it there- 
by become a possible source of malignancy? 
Could such a strain spread throughout a 
human population? What would be the 
consequences if even an insulin secreting 
strain became an intestinal resident? 
Not to mention the more malign or just 
plain stupid scenarios such as those 
which depict the insertion of the gene 
for botulinus toxin into Escherichia coli. 
"Unfortunately the answers to 
these questions in terms of probabilities 
that some of these strains could persist 
in the intestines, the probabilities that 
the modified plasmids might be trans- 
ferred to other strains, better adapted 
to intestinal life, the probabilities 
that the genome of an oncogenic virus 
could escape, could be taken up, could 
transform a host cell, are all largely 
unknown." 
15. The experiments which the defendants intend to 
conduct at Ft. Detrick includes the use of Polyoma, a virus which 
[Appendix C — 40] 
