- 2 - 
(pSClOl) and xl776 (pCRl)." Appended to this memorandum were hundreds 
of pages of documentation, arranged under Tabs A through L. A copy of 
this December 2, 1976, memorandum with all attachments (except that, 
for the sake of brevity, the 147-page submission appearing under Tab E 
has been omitted) is appended to this affidavit (this will hereinafter 
be called the December 2, 1976, memorandum). 
7. Under Tab B of the December 2, 1976, memorandum is a copy of the 
Boston Area Recombinant DNA Group Critique. 
8. Under Tab A of the December 2, 1976, memorandum is a detailed 
letter to Dr. Fredrickson, Director, NIH, from Dr. Edward Adelberg, 
Professor of Human Genetics, School of Medicine, Yale University, and 
Chairman of the Working Group on Safer Hosts and Vectors responding point- 
by-point to the Boston Area Recombinant DNA Group Critique. 
9. Under, Tab C of the December 2, 1976, memorandum appears a 
memorandum describing my telephone calls to the four other members of 
Group 1 (Host-plasmids) of the Working Group on Safer Hosts and Vectors. 
They all agreed with Dr. Adel berg's response to the Boston Area Recombinant 
DNA Group Critique. 
10. Tab D of the December 2, 1976, memorandum contains a history of 
the detailed and extremely careful steps taken toward the certification 
of x! 776 (pSClOl) and xl 776 (pCRl) as EK2 host-vector systems. Tabs E 
through K contain voluminous documentation referred to under Tab D. 
11. Tab L contains the memorandum signed by Dr. Fredrickson on 
December 6, 1976, certifying xl 776 (pSClOl) and xl 776 (pCRl) as EK2 
host-vector systems. 
Bernard Talbot, M.D., Ph.D. 
Special Assistant for Intramural Affairs 
National Institutes of Health 
SUBSCRIBED AND SWORN TO BEFORE ME 
THIS 7^ DAY OF. -4 * 
Notary Public 
f^y commission expires My commi-sior, «»p"qs July l , 19/8. 
[Appendix C — 220] 
