PREFACE 
This is the eighteenth in a series constituting a "public record" of activities in regard to the 
National Institutes of Health (NIH) Guidelines for recombinant DNA research. 
The first seventeen volumes cover events from February 1975 through June 1993. This 
eighteenth volume covers events from June 1993 through December 1993. 
Starting from Volume 14, human gene transfer/therapy protocols that have been approved 
by the NIH Recombinant DNA Advisory Committee, are collected. Documents of each 
human study include the clinical protocol, the Informed Consent document describing the 
study in a nontechnical language, both scientific and nontechnical abstracts, and curriculum 
vitae of the principal investigators. 
Volumes 1 through 5 in this series and the Environmental Impact Statement may be 
purchased from the Superintendent of Documents, U.S. Government Printing Office (GPO), 
Washington, DC 20402 or GPO bookstores in selected cities throughout the United States. 
They may also be viewed in some 600 public libraries of the GPO depository system. The 
GPO stock numbers are: Volume 1, 017-004-00398-6; Volume 2, 017-040-00422-2; Volume 
2 Supplement (Environmental Impact Statement), 017-040-00413-3; Volume 3, 017-040- 
00429-0; Volume 3 Appendices, 017-040-0043-3; Volume 4, 017-040-00443-5; Volume 4 
Appendices 017-040-00422-7; and Volume 5, 017-040-00470-2. Volumes 6 through 16 are 
available from the Office of Recombinant DNA Activities, National Institutes of Health, 
Bethesda, MD 20892, USA. 
Recombinant DNA Research, Volume 18 
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