Non-Technical Abstract 
17.0 Non-technical Abstract 
Infection by the human immunodeficiency virus (HIV) leads to 
progressive loss of the body's immune defenses against infectious 
agents. Persistent HIV infection therefore leads to an acquired 
immunodeficiency syndrome (AIDS) , for which there are currently 
no curative treatments. It has recently become clear that the 
introduction of specific genes into T cells can provide 
protective effects against HIV growth in the laboratory. One of 
these protective genes is an altered inactive form of an 
essential viral gene, called Rev. Expression of this altered 
form of Rev, called Rev M10, inhibits normal Rev function and 
blocks productive HIV replication. In this study, we propose to 
determine whether Rev M10 can improve the survival of T cells in 
humans. If this approach proves successful, it could provide the 
basis to develop Rev M10 as a molecular genetic intervention for 
the treatment of AIDS. 
Recombinant DNA Research, Volume 18 
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