Cone. Nevirapine nM 
0 -gal 
No. of Stained Cells 
0 
206 
40 
167 
100 
236 
200 
211 
400 
196 
Table 1. 
Effect of Nevirapine on Amphotrophic Retrovirus Integration 
Amphotrophic pLJ-0gal supernatants (200 /il) produced from 
7 CRIP cells were innoculated onto 293 cells growing in 8 well 
plates. The wells contained 2 mis of medium with the indicated 
concentrations of Nevirapine. After 3 days of incubation, cells 
were fixed and stained for 0-gal activity by X-gal staining and 
the number of positive cells per 6 cm 2 well counted. Control 
transduced cells showed no X-gal staining. In addition, no 
toxicity of the drug was evident. 
Days Post HIV 
Infection 
RT Activity cpm 
+ Nevirapine Control 
5 
271 
745 
7 
310 
• 1950 
10 
165 
5147 
14 
235 
1861 
Table 2. Effect of Nevirapine on HIV replication in PBL 
Recombinant DNA Research, Volume 18 
[39] 
