to HIV infection in vitro was confirmed, followed by adoptive 
transfer of these cells into SCID-HU mouse recipients followed by 
infection with virus in vivo. These studies are ongoing, and the 
results will be presented when available. 
Finally, we have also attempted to model the experimental 
design in this murine system. A population of CD4 + cells is 
transduced with the vector proposed for use in this study. When 
these cells are transduced in two populations and inoculated into 
the SCID-HU mice, their survival can be monitored in vivo by 
limiting dilution analysis. These studies are currently in 
progress, and their status will be summarized at the time of the 
RAC meeting if these results are available. Although we have 
utilized this animal model, it is clear that it is not a suitable 
model for HIV infection and its many manifestations in man. The 
definitive study can only be performed in humans. 
Recombinant DNA Research, Volume 18 
[41] 
