HUMAN GENE TRANSFER PROTOCOL 
9306-050 
Raffel, Corey, Childrens Hospital Los Angeles, Los Angeles, California, 
and Culver, Kenneth, Iowa Methodist Medical Center, Des Moines, Iowa; 
Gene Therapy for the Treatment of Recurrent Pediatric Malignant 
Astrocytomas with In Vivo Tumor Transduction with the Herpes Simplex 
Thymidine Kinase Gene. 
Date of RAC Approval: 6/8/1993 
Date of NIH Approval: 9/3/1993 
Recombinant DNA Research, Volume 18 
[49] 
