PROPOSAL FOR A PHASE ONE GENE 
THERAPHY CLINICAL STUDY 
Project Title 
Gene Therapy for Human Brain Tumors Using 
Episome-based 
Antisense cDNA Transcription of Insulin- 
like Growth Factor I 
Names of investigators: 
Principal Investigator: 
Joseph Ilan, PhD, Dept, of Pathology (216/368-3590) 
Co-Principal Investigators: 
Robert A. Ratcheson, M.D., Chief Neurosurgery, University Hospitals 
Donald D. Anthony, M.D., Ireland Cancer Center, Dept, of Pharmacology 
Mark L. Tykocinski, M.D., Dept, of Pathology 
Associate Investigators: Neurosurgery 
Robert Fenstermaker, M.D. 
Edward Ganz, M.D. 
Timothy B. Mapstone, M.D. 
Associate Investigators: Gene Therapy 
and Immunology 
Judith Ilan, PhD 
David Kaplan, M.D. PhD 
Thomas R. Johnson, PhD 
Associate Investigator: Neuropathology 
Pierluigi Gambetti, M.D. 
Institutions: Case Western Reserve University School of Medicine and University Hospitals of 
Cleveland. 
Estimated Duration of Study: 3 years 
Number and Kind of Subjects: Number Sex Ag e 
Patients with Glioblastoma multiforme 12 M & F >18 
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