* * * TABLE OF CONTENTS * * * 
I-A. Call to Order 5 
I-B. Update on the Letter Sent to the NIH Director Regarding Compensation 
for Research-Related Injuries/Dr. Walters 5 
I-C. Executive Secretary Report on Possible Adverse Effects/Dr. Wivel 6 
I-D. Recognition for Service on the RAC/Dr. Walters 6 
II. Minutes of the June 7-8, 1993, RAC Meeting 6 
ni-A. Chair Report on RAC-Approved Human Gene Transfer Protocols 
/Dr. Walters 7 
III-B. Chair Report on Minor Modifications to NIH-Approved Human 
Gene Transfer Protocols/Dr. Walters 7 
IV. Addition to Appendix D of the NIH Guidelines Regarding a 
Human Gene Therapy Protocol Entitled: Phase I Study of 
Transfected Cancer Cells Expressing the Interleukin-2 Gene 
Product in Limited Stage Small- Cell Lung Concert 
Drs. Cassileth, Podack, Sridhar, and Savaraj 7 
V. Addition to Appendix D of the NIH Guidelines Regarding a 
Human Gene Therapy Protocol Entitled: Retroviral Mediated 
Transfer of the Human Multi-Drug Resistance Gene (MDR-1 ) 
Into Hematopoietic Stem Cells During Autologous Transplantation 
After Intensive Chemotherapy for Breast Cancer /Dr. O'Shaughnessy 10 
VI. Major Amendment to Appendix D-XXVII of the NIH Guidelines 
Regarding a Human Gene Transfer Protocol Entitled: Phase I 
Study to Evaluate the Safety of Cellular Adoptive Immunotherapy 
Using Genetically Modified CD8( + ) HIV-Specific T Cells in HIV 
Seropositive Individuals /Drs. Greenberg and Riddell 13 
VII-A. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitled: Gene Therapy for Recurrent 
Pediatric Brain Tumors /Drs. Kun, Sanford, Brenner, Heideman, 
and Oldfield 15 
VII-B. RAC Recommendations Regarding the Establishment of a Working 
Group to Develop Guidelines for Informed Consent Documents 17 
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