Recombinant DNA Advisory Committee - 09/9-10/93 
VTII. Amendment to the Guidelines for the Submission of Human Gene 
Transfer /Therapy Protocols for Review by the RAC of the Points 
to Consider/NIH Guidelines /Dr. Wivel 18 
IX. Working Group Report on Categories of Human Gene Transfer 
Experiments that are Exempt from RAC Review/Dr. Parkman 19 
X. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitled: Immunization of Malignant 
Melanoma Patients with Interleukin-2 Secreting Melanoma Cells 
Expressing Defined Allogeneic Histocompatibility Antigens I 
Drs. Das Gupta and Cohen 21 
XI. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitied: A Phase I Clinical Trial to 
Evaluate the Safety and Effects in HIV-1 Infected Humans of 
Autologous Lymphocytes Transduced with a Ribozyme that Cleaves 
HIV-1 RNA/Dts. Wong-Staal and Poeschla 23 
XII. Addition to Appendix D of the NIH Guidelines Regarding a Human 
Gene Therapy Protocol Entitled: Genetically Engineered 
Autologous Tumor Vaccines Producing Interleukin-2 for the Treatment 
of Metastatic Melanoma /Dts. Economou and Glaspy 27 
XIII. Addition to Appendix D of the NIH Guidelines Regarding Semliki 
Forest Virus (SFV) Vector Expression System- Reduction in Physical 
Containment from BL3 to BL2 /Dt. Temple 30 
XIV. Amendment to Appendix B of the NIH Guidelines Regarding Updating 
the Classification of Microorganisms/Dr. Fleming 32 
XV. Amendments to Section III, IV, V, and Appendix C and F of the NIH 
Guidelines Regarding the Cloning of Toxin Molecules/Dr. Wivel 33 
XVI. Amendments to Section III and Appendix D of the NIH Guidelines 
Regarding Actions Taken Under the Guidelines/Dr. Wivel 38 
XVII. Working Group Report on Categories of Human Gene Transfer 
Experiments that are Exempt from RAC Review/Dr. Parkman 38 
xvm. Future Meetings of the RAC 39 
XIX. Adjournment 39 
Attachments I - Roster 
II - Approved Human Gene Transfer Protocols 
III - Minor Modifications 
Recombinant DNA Research, Volume 18 
[ 181 ] 
