HUMAN GENE TRANSFER PROTOCOLS 
8810-001* 
9007-002** 
9007-003 
9102-004* 
9105-005* 
(M) Rosenberg, Steven A., National Cancer Institute; The Treatment of 
Patients with Advanced Cancer Using Cyclophosphamide , Interleukin-2 
and Tumor Infiltrating Lymphocytes. 
Date of RAC Approval: 10-3-88 
Date of NIH Approval: 3-2-89 
Minor Modification: 3-30-90 
(T) Blaese, R. Michael, National Cancer Institute; Treatment of Severe 
Combined Immune Deficiency (SCID) due to Adenosine Deaminase 
(ADA) Deficiency with CD34(+) Selected Autologous Hematopoietic 
Stem Cells 
Date of RAC Approval: 7-31-90 
Date of NIH Approval: 9-6-90 
Major Amendment-Date of RAC Approval: 2-10-92 
Major Amendment-Date of NIH Approval: 4-22-92 
Minor Modification: 4-21-93 
Minor Modification: 6-7-93 
(T) Rosenberg, Steven A., National Cancer Institute; Gene Therapy of 
Patients with Advanced Cancer Using Tumor Infiltrating Lymphocytes 
Transduced with the Gene Coding for Tumor Necrosis Factor. 
Date of RAC Approval: 7-31-90 
Date of NIH Approval: 9-6-90 
(M) Brenner, Malcolm K.; Mirro, Joseph; Hurwitz, Craig; Santana, Victor; 
and Ihle, James, St. Jude Children's Research Hospital; Autologous 
Bone Marrow Transplant for Children with Acute Myelogenous Leukemia 
in First Complete Remission: Use of Marker Genes to Investigate the 
Biology of Marrow Reconstitution and the Mechanism of Relapse. 
Date of RAC Approval: 2-4-91 
Date of NIH Approval: 7-12-91 
Minor Modification: 11-91 
(M) Brenner, Malcolm K.; Mirro, Joseph; Santana, Victor; and Ihle, James, 
St. Jude Children's Research Hospital; A Phase //// Trial of High Dose 
Carboplatin and Etoposide with Autologous Marrow Support for 
Treatment of Stage D Neuroblastoma in First Remission: Use of Marker 
Genes to Investigate the Biology of Marrow Reconstitution and the 
Mechanism of Relapse. 
Date of RAC Approval: 5-31-91 
Date of NIH Approval: 7-12-91 
Minor Modification: 11-91 
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