9110-012* 
9202-013* 
9202-014 
9202-015 
9202-016* 
9202-017 
(T) Wilson, James M., University of Michigan; Ex Vivo Gene Therapy of 
Familial Hypercholesterolemia. 
Date of RAC Approval: 10-8-91 
Date of NIH Approval: 11-14-91 
Minor Modification: 12-3-92 
Minor Modification: 8-18-93 
(T) Nabel, Gary J., University of Michigan; Immunotherapy of Malignancy 
by In Vivo Gene Transfer into Tumors. 
Date of RAC Approval: 2-10-92 
Date of NIH Approval: 4-17-92 
Minor Modification: 1-22-93 
Minor Modification: 1-93 
(M) Cometta, Kenneth, Indiana University; Retroviral-Mediated Gene 
Transfer of Bone Marrow Cells during Autologous Bone Marrow 
Transplantation for Acute Leukemia. 
Date of RAC Approval: 2-11-92 
Date of NIH Approval: 4-17-92 
(M) Economou, James S. and Belldegrun, Arie, University of California at 
Los Angeles; The Treatment of Patients with Metastatic Melanoma and 
Renal Cell Cancer Using In Vitro Expanded and Genetically-Engineered 
(Neomycin Phosphotransferase) Bulk, CD8 (+) and/or CD4( + ) Tumor 
Infiltrating Lymphocytes and Bulk, CD8( + ) and/or CD4( + ) Peripheral 
Blood Leukocytes in Combination with Recombinant Interleukin-2 Alone, 
or with Recombinant Interleukin-2 and Recombinant Alpha Interferon. 
Date of RAC Approval: 2-11-92 
Date of NIH Approval: 4-17-92 
(T) Freeman, Scott M., University of Rochester School of Medicine, 
Rochester, New York; Gene Transfer for the Treatment of Cancer. 
Date of RAC Approval: 2-10-92 
Date of NIH Approval: 2-5-93 
Minor Modification: 8-6-93 
(M) Greenberg, Philip D. and Riddell, Stanley, University of Washington, 
Seattle; Phase I Study of Cellular Adoptive immunotherapy Using 
Genetically Modified CD8+ HIV-Specific T Cells for HIV-Seropositive 
Patients Undergoing Allogeneic Bone Marrow Transplant. 
Date of RAC Approval: 2-11-92 
Date of NIH Approval: 4-17-92 
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Recombinant DNA Research, Volume 18 
