9212-036 
9303-037 
9303-038 
9303-039 
9303-040 
9303-041 
(M) Welsh, Michael J., Howard Hughes Medical Institute and Smith, Alan 
E.; Genzyme Corporation; Cystic Fibrosis Gene Therapy Using an 
Adenovirus Vector: In Vivo Safety and Efficacy in Nasal Epithelium. 
Date of RAC Approval: 12-4-92 
Date of NTH Approval: 4-16-93 
(T) Culver, Kenneth W., Iowa Methodist Medical Center, Des Moines, 
Iowa, and Van Gilder, John C.; University of Iowa, Iowa City, Iowa; 
Gene Therapy for the Treatment of Malignant Brain Tumors with In Vivo 
Tumor Transduction with the Herpes Simplex Thymidine Kinase 
Gene/Ganciclovir System. 
Date of RAC Approval: 3-1-93 
Date of NIH Approval: 4-16-93 
(M) Heslop, Helen E.; Brenner, Malcolm K.; and Rooney, Cliona, St. Jude 
Children's Research Hospital, Memphis, Tennessee; Administration of 
Neomycin Resistance Gene Marked EBV Specific Cytotoxic T 
Lymphocytes to Recipients of Mismatched-Related or PhenotypicaBy 
Similar Unrelated Donor Marrow Grafts. 
Date of RAC Approval: 3-2-93 
Date of NIH Approval: 4-16-93 
(M) Brenner, Malcolm K.; Krance, Robert; Heslop, Helen E.; Santana, 
Victor; and Ihle, James, St. Jude Children's Research Hospital, 
Memphis, Tennessee; Assessment of the Efficacy of Purging by Using 
Gene-Marked Autologous Marrow Transplantation for Children with 
Acute Myelogenous Leukemia in First Complete Remission. 
Date of RAC Approval: 3-2-93 
Date of NIH Approval: 4-16-93 
(T) Simons. Jonathan. Johns Hopkins Oncology Center. Baltimore. 
Maryland: Phase I Study of Non- Replicating Autologous Tumor Cell 
Injections Using Cells Prepared With or Without Granulocyte- M acrophage 
Colony Stimulating Factor Gene Transduction in Patients with Metastatic 
Renal Cell Carcinoma. 
Date of RAC Approval: 3-1-93 
(T) Wilmott, Robert W. and Whitsett, Jeffrey, Children's Hospital Medical 
Center, Cincinnati, Ohio, and Trapnell, Bruce; Genetic Therapy, Inc., 
Gaithersburg, Maryland; A Phase I Study of Gene Therapy of Cystic 
Fibrosis Utilizing a Replication Deficient Recombinant Adenovirus Vector 
to Deliver the Human Cystic Fibrosis Transmembrane Conductance 
Regulator cDNA to the Airways. 
Date of RAC Approval: 3-2-93 
Date of NIH Approval: 4-16-93 
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Recombinant DNA Research, Volume 18 
