NabeL, Gary J., University of Michigan Medical Center, Ann Arbor, 
Michigan; A Molecular Genetic Intervention for AIDS - Effects of a 
Transdominant Negative Form of Rev. 
Date of RAC Approval: 6-7-93 
Date of NIH Approval: 9-3-93 
Raffel, Corey, Childrens Hospital Los Angeles, Los Angeles, 
California, and Culver, Kenneth, Iowa Methodist Medical Center, Des 
Moines, Iowa; Gene Therapy for the Treatment of Recurrent Pediatric 
Malignant Astrocytomas with In Vivo Tumor Transduction with the 
Herpes Simplex Thymidine Kinase Gene. 
Date of RAC Approval: 6-8-93 
Date of NIH Approval: 9-3-93 
Hesdorffer, Charles and Amman, Karen, Columbia University College 
of Physicians and Surgeons, New York, New York; Human MDR Gene 
Transfer in Patients with Advanced Cancer. 
Date of RAC Approval: 6-8-93 
Date of NIH Approval: 9-3-93 
Ilan. Joseph. Case Western Reserve University School of Medicine and 
University Hospitals of Cleveland. Cleveland. Ohio; Gene Therapy for 
Human Brain Tumors Using Episome-Based Antisense cDNA 
Transcription of Insulin-Like Growth Factor I, 
Date of RAC Approval; 6-8-93 
M = Human Gene Marking Protocol 
T = Human Gene Therapy Protocol 
* = Minor Modification 
** = Major Amendment 
_ = RAC Approved/NIH Approval Pending 
T 
M 
Total (T + M) 
RAC APPROVED 
29 
23 
52 
NIH DIRECTOR APPROVED 
24 
22 
46 
September 7, 1993 
9306-049 (T) 
9306-050 (T) 
9306-051 (T) 
9306-052 (T) 
[ 236 ] 
Recombinant DNA Research, Volume 18 
