TABLE OF CONTENTS 
Non-Technical and Scientific Abstract 
Summary of Revisions 
Points to Consider with the Gene Therapy Trial 
Phase I Study of Transfected Cancer Cells Expressing 
the Interleukin-2 Gene Product in Limited Stage Small 
Cell Lung Cancer 
1. Background and Preliminary Studies 
\ • 
2. Proposal Protocols and Experimental Details 
3. Eligibility Criteria For Entry on Study 
4. Treatment Plan 
5. Toxicity Assessment and Reporting 
6. Criteria for Clinical Evaluation and Definition of Response 
7. Study Parameters 
8. Statistical Considerations 
9. References 
IRB, IBC and Informed Consent Form 
Curricula Vitae 
Laboratory Data 
Sequences and Vector Map(s) 
Manuscripts 
i 
1 
ii ! 
i 
m i 
IV 
7-8 
.... 8-16 
I 
. . . 16-17 1 
17 
l 
. . . 17-18 
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. . . 18-19 | 
. . . 19-25 
Appendix A 
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Appendix B 
i 
Appendix C 
Appendix D 
Appendix E 
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Recombinant DNA Research, Volume 18 
