558-45-1203 
Podack, Eckhard R. 
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Hameed, A., Olsen, K.J., Lee, M.-K., Lichtenheld, M.G., and Podack, E.R. (1989) Cytolysis by Ca permeablej 
transmembrane channels: Pore formation causes extensive DNA degradation and cell lysis^ J. Exp Med. 1 69:765. i 
Podack, E.R. and Hengartner, H. Structure of Perforin and its role in Cytolysis. Immunol. Res -' ' 1 9 ® 9 - ; 
Muller, C., Kagi, D., Aebischer, T., Odermatt, B., Podack, E.R., Zinkernagel, R.M., Hengartner, H. (1989) Detection of 1 
Perforin and Granzyme A mRNAs in infiltrating cells during LCMV infection of mice. Eur. J. Immunol., 19:1253-1259. \ 
Podack, E.R. (1989) Killer (K) arid Natural Killer (NK) Cells: Function of Non MHC restricted Killer Cells. Clinical Aspects f 
of Immunology 5th ed. , (England: Blackwell Scientific Publication LTD, in press. 
Podack, E.R. (1989) Killer Lymphocytes and How They Kill. In: Current Opi n i on in Cell Blol ° . qY/ 1 :929 - 
Mittelman, A., Savona, S., Gafney, E., Penichet, K.O., Lin, B., Levitt, D., Ahmed, T., Arlin, Z.A., Baskind, P., I 
Needleman, D., Levere, R.D., and Podack, E.R. (1989) Treatment of Patients with Advanced Cancer Using Multiple 
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Long-Term Cultured Lymphokine-Activated Killer (LAK) Cell Infusions and Recombinant Human lnterleukin-2. J. Biol. 
Response Mod., 8:468-478. 
Lichtenheld, M.G. and Podack, E.R. (1989) Structure of the Human Perforin Gene: A Simple Gene Organization with|y S j 
Interesting Potential Regulatory Sequences. J. Immunol., 143,4267-4274. 
Nagler-Anderson, C., Lichtenheld, M.G., Eisen, N.N., and Podack, E.R. (1 989) Perforin is present in primary peritoneal jim 
exudate cytotoxic T-cells. J. Immunol., 143:3440-3443. 
Podack, E.R., and Lichtenheld, M. (1990) Perforin and the mechanism of lymphocyte mediated cytolysis. In: Current 
Topics, ed. Toni Claudio, (California: Academic Press), 36:161-175. 
Asch, E. & Podack, E.R. (1990) Vitronectin Binds to Activated Human Platelets and Plays a Role in Platelet Aggregation. 
J. Clin. Invest. 85:1372-1378. 
Podack, E.R. (1990) Expression of Perforin and Granzymes and their Role in Cytolysis. In: Local Immunity, eds. Clemens 
Sorg, 6:1 36. 
Podack, E.R. & Hengartner, H. (1990) Structure of Perforin & Its Role in Cytolysis. Year in Immunol. ,6:245. 
Podack, E.R., Hengartner, H. and Lichtenheld, M.G. (1991 ) A Central Role of Perforin in Cytolysis? Ann. Rev. Immuno., 
9:129-152. 
Podack, E.R. and Kupfer, A.K. (1991) T-cell effector functions. Annual Review of Cell Biology, 7:479. 
Clement, M.V., Haddad, P., Soulie, A., Benvenuti, C., Lichtenheld, M.G., Podack, E.R., Sigaux, N. and Sasportes 
(1991) Perforin and granzyme B as markers for acute rejection in heart transplantation. International Immunology, 
3:1 175. 
Podack, E.R. (1992) Perforin: Structure, function and regulation. In: Current Topics of Microbiology and Immunology ,! 
(Springer-Verlag Berlin-Heidelberg) 178:175. 
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Keane, R.W., Tallent, M.W., and Podack, E.R. (1992) Resistance and Susceptibility of Neural Cells to Lysis by Cytotoxic 
Lymphocytes and by Cytolytic Granules. Transplantation. 54:520. 
Lu, P., Garcia-Sanz, J.A., Lichtenheld, M.G. and Podack, E.R. (1992) Perforin Expression in Human Peripheral Blood 
Mononuclear Cells. J. Immunol. 148:3354-3360. 
Ohe, Y., Podack, E.R., Olsen, K.J., Miyahar, Y., Miura, K., Sasaki, Y., Tamura, T., and Saijo, N. (1993) Combination 
Effect of Vaccination with IL2 and IL4 cDNA Transfected Cells on the Induction of a Therapeutic Immune Response 
Against Lewis Lung Carcinoma Cells Int. J. of cancer. 53:432-437. 
Hameed, A., Olsen, K,J., Cheng, L., Fox, W.M., Hruban, R.H. and Podack, E.R. (1992) Immunohistochemical 
Identification of Cytotoxic Lymphocytes Using Human Perforin Monoclonal Antibody. Am. J. Pathol. 140:1025. 
Lichtenheld, M.G. and Podack, E.R. (1992) Structure and Fucntion of the Murine Perforin Promoter and Upstream 
Region: Reciprocal gene activation or silencing in perforin positive and negative cells. J. Immunol. 149:2619. 
Ohe, Y., Podack, E.R., Olsen, K.J., Miyahara, Y., Miura, K., Saito, H., Koishihara, Y., Ohsugi, Y., and Saijo, N. (1993) 
lnterleukin-6 cDNA Transfected Lewis Lung Carcinoma Cells are unable to Induce and Immune Response but cause 
Cachexia in Syngeneic Mice. Brit. J. Cancer 67:939. 
Ge Deng and Eckhard R. Podack. (1993) Suppression of apoptosis in a cytotoxic T cell line by interleukin-2 mediated 
gene transcription and deregulated expression of the proto-oncogene bcl2. Proc. Natl. Acad. Sci. USA 90:21 89-2193. 
Bowen, M.A., Olsen, K.J., Cheng, L., Avila, D. and Podack, E.R. (1993) Functional Effects of CD30 on a Large 
Granular-Lymphoma Cell Line, YT : Inhibition of Cytotoxicity, Regulation of CD28 and IL-2R, and induction of Homotypic 
Aggregation. Submitted. 
Ohmori, Y., Podack, E.R., Nishio, K., Takahashi, M., Miyahara, Y„ Takeda, Y., Kubota, N., Funayama, T., Ogasawara, 
H., Ohira, T., Ohta, S. and Saijo, N. (1993) Apoptotic Cell Death Caused By Anti-Cancer Agents is Inhibited by bcl-2. 
Biochemical and Biophysical Research Communications 192:30. 
Garcia-Sanz, J.A. and Podack, E.R. (1993) Regulation of Perforin Gene Expression in a T cell Hybrid with Inducible 
Cytolytic Activity. Eur. J. Immunol, in press. 
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Recombinant DNA Research, Volume 18 
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